Late Show with David Letterman - Season 22

1. Luke Wilson, Julie Chen, Lee Brice

Aired: 9/2/2014

2. Kristen Wiig, Sen. Elizabeth Warren, The New Pornographers

Aired: 9/3/2014

3. Steve Buscemi, Indy Car Season Champ, Alt-J

Aired: 9/4/2014

4. Tina Fey, Moody McCarthy, Kevin Drew

Aired: 9/5/2014

5. Bill Maher, Henrik Lundqvist, Spoon

Aired: 9/8/2014

6. Michael Strahan, Richard Branson, Interpol

Aired: 9/9/2014

7. Dr. Phil, Katharine McPhee, Death from Above 1979, Ray Benson

Aired: 9/10/2014

8. Jason Bateman, Billy Eichner, Ryan Adams

Aired: 9/11/2014

9. Mindy Kaling, Jake Johannsen, Maddie & Tae

Aired: 9/12/2014

10. Mark Harmon, "Jungle" Jack Hanna

Aired: 9/22/2014

11. Denzel Washington, Lenny Kravitz

Aired: 9/23/2014

12. Kelly Ripa, Jim Gaffigan, Paloma Faith

Aired: 9/24/2014

13. Jerry Seinfeld, Michael Jackson ONE

Aired: 9/25/2014

14. Ted Danson, Andrew Norelli

Aired: 9/26/2014

15. Neil Patrick Harris, Jamie Oliver, Aretha Franklin

Aired: 9/29/2014

16. John Oliver, Maggie Q, Bleachers

Aired: 9/30/2014

17. Bill O'Reilly, Cristin Milioti

Aired: 10/1/2014

18. Johnny Galecki, Andre Benjamin, Delta Spirit

Aired: 10/2/2014

19. Mariska Hargitay, Simon Amstell, Kandace Springs

Aired: 10/3/2014

20. Aziz Ansari, Tom Dreesen

Aired: 10/6/2014

21. Robert Downey Jr., Sarah Paulson, Lizzo

Aired: 10/7/2014

22. Anderson Cooper, Gina Rodriguez, Hatsune Miku

Aired: 10/8/2014

23. Robert Duvall, Elle Fanning, Rival Sons

Aired: 10/9/2014

24. Chelsea Handler; Keegan-Michael Key and Jordan Peele; Angaleena Presley

Aired: 10/10/2014

TV host Chelsea Handler; comics Keegan-Michael Key and Jordan Peele; Angaleena Presley performs.

25. Russell Brand, Dave Grohl, Foo Fighters

Aired: 10/13/2014

26. Michael Keaton, Foo Fighters

Aired: 10/14/2014

27. Bill Murray, Foo Fighters

Aired: 10/15/2014

28. Tom Selleck, Jenny Slate, Foo Fighters

Aired: 10/16/2014

29. Jessica Chastain, Lenny Marcus, Foo Fighters

Aired: 10/17/2014

30. Amy Poehler, Sen. Jeff Flake, Sen. Martin Heinrich, Mastodon, Jerry Lee Lewis

Aired: 10/27/2014

31. Taylor Swift, Tom Mison

Aired: 10/28/2014

32. Jim Carrey, David Tennant

Aired: 10/29/2014

33. Brian Williams, Perfume Genius

Aired: 10/30/2014

34. Keith Olbermann, Brian Regan, Run the Jewels

Aired: 10/31/2014

35. Martin Short, Father John Misty

Aired: 11/3/2014

36. Jennifer Lopez, Rob Riggle, Kimbra

Aired: 11/5/2014

37. Whoopi Goldberg, Jimmy Page, Mapei

Aired: 11/6/2014

38. Amy Schumer, Jeff Caldwell

Aired: 11/7/2014

39. Katie Holmes, Alex Zanardi

Aired: 11/10/2014

40. Steve Carell, Martha Stewart, OK Go

Aired: 11/11/2014

41. Jennifer Lawrence, Boris Johnson

Aired: 11/12/2014

42. Jon Stewart, Shawn Mendes

Aired: 11/13/2014

43. Kristin Chenoweth; Chris Young

Aired: 11/14/2014

Actress Kristin Chenoweth; Chris Young performs.

44. Jason Sudeikis, Allison Janney, Damien Rice

Aired: 11/17/2014

45. Stupid Pet Tricks, Charlie Day, Hiss Golden Messenger

Aired: 11/18/2014

46. Regis Philbin, Hundred Waters

Aired: 11/19/2014

47. Edward Norton, Jessye Norman

Aired: 11/20/2014

48. Norman Lear, TV on the Radio

Aired: 11/21/2014

49. Seth Rogen, Amy Sedaris

Aired: 11/24/2014

50. Emily Blunt, Adam Resnick, Wu-Tang Clan

Aired: 11/25/2014

51. Jake Gyllenhaal, Dr. John P. Holdren, Nico & Vinz

Aired: 11/26/2014

52. Joaquin Phoenix, Cristela Alonzo, Al Green

Aired: 12/8/2014

53. Ben Stiller, Olivia Munn, LaLa Brooks

Aired: 12/9/2014

54. Meryl Streep, Rebel Wilson, J. Cole

Aired: 12/10/2014

55. Chris Rock, Sting

Aired: 12/11/2014

56. Jamie Foxx, Robert Klein, Dan Penn

Aired: 12/12/2014

57. Emma Stone Top, Marcus Mariota, Bob Seger

Aired: 12/15/2014

58. New Holiday Toys, Anna Kendrick, Charli XCX

Aired: 12/16/2014

59. Tom Brokaw, Will Nelson & Billy Joe Shaver

Aired: 12/17/2014

60. Rosie O’Donnel,l Jeff Altman

Aired: 12/18/2014

61. Jay Thomas, Josh Brolin, Darlene Love

Aired: 12/19/2014

The final Christmas episode. Jay Thomas drops by to once again tell "The best talk show story, ever", then he and David try to knock the meatball off the Christmas tree in the Late Show Quarterback Challenge. An interview with Josh Brolin. The show wraps up with Darlene Love's last Late Show performance of Christmas (Baby Please Come Home).

62. Kathy Griffin, David Oyelowo, Lera Lynn

Aired: 1/5/2015

63. Ethan Hawke, Allison Williams, Parquet Courts

Aired: 1/6/2015

64. Julianne Moore, Catfish & the Bottlemen

Aired: 1/7/2015

65. Donald Trump, Chelsea Peretti, Foxygen

Aired: 1/8/2015

66. Michael Somerville, Nicole Atkins

Aired: 1/9/2015

67. Gordon Ramsay, Adam Devine, St. Paul and the Broken Bones

Aired: 1/12/2015

68. Anderson Cooper, Shovels & Rope

Aired: 1/13/2015

69. Amanda Peet, Ryn Weaver

Aired: 1/14/2015

70. Larry David, Dan Patrick, Sleater-Kinney

Aired: 1/15/2015

71. Urban Meyer, Johnny Beehner, Ella Henderson

Aired: 1/16/2015

72. Louis CK, Nicolle Wallace, the Lone Bellow

Aired: 1/26/2015

73. Andrew Luck, Oscar Isaac, Drenge

Aired: 1/27/2015

74. Viola Davis, Ben Schwartz, Marty Stuart

Aired: 1/28/2015

75. John Oliver, Mayim Bialik, Death Cab for Cutie

Aired: 1/29/2015

76. Aziz Ansari, Brian Kiley, Ben Howard

Aired: 1/30/2015

77. Jack Hanna, Sharon Jones and the Dap-Kings

Aired: 2/2/2015

78. Dr. Phil McGraw, Robin Tunney, Diana Krall

Aired: 2/3/2015

79. Ryan Reynolds, Dierks Bentley

Aired: 2/4/2015

80. Martin Short, Bettye Lavette

Aired: 2/5/2015

81. Sienna Miller, Andy Kindler, Bob Mould

Aired: 2/6/2015

82. Steve Carell, Dr. Cornel West

Aired: 2/9/2015

83. Courtney Love, Chris Elliott, Rhiannon Giddens

Aired: 2/10/2015

84. Bill Belichick, Elisabeth Moss, Madisen Ward and the Mama Bear

Aired: 2/11/2015

85. Tom Hanks, Sturgill Simpson

Aired: 2/12/2015

86. Bill Hader, Pat McGann, Shakey Graves

Aired: 2/13/2015

87. Matthew Perry, Adam Scott, Kishi Bashi

Aired: 2/16/2015

88. Dakota Johnson, David Tochinskiy, Twin Shadow

Aired: 2/17/2015

89. Will Smith, Grizfolk

Aired: 2/18/2015

90. Don Cheadle, Ilana Glazer & Abbi Jacobson, Mikky Ekko

Aired: 2/19/2015

91. Kid Scientists, Sean Hayes, Judah & the Lion

Aired: 2/20/2015

92. Helen Mirren, the 2015 Daytona 500 winner, Steve Earle

Aired: 2/23/2015

93. Matthew Broderick, Ellie Kemper, JD McPherson

Aired: 2/24/2015

94. Julianna Margulies, Eric Ripert, Glass Animals

Aired: 2/25/2015

95. Kevin Spacey, Lily James, Alabama Shakes

Aired: 3/9/2015

96. Patricia Arquette, Will Butler

Aired: 3/10/2015

97. Kelsey Grammer, Stevie Wonder

Aired: 3/11/2015

98. Lena Dunham, Bobby Cannavale, Andy Kim with Kevin Drew

Aired: 3/12/2015

99. Kevin Bacon, Jimmie Walker, Airborne Toxic Event

Aired: 3/13/2015

100. Shailene Woodley, Dr. Cornel West, Matthew E. White

Aired: 3/16/2015

101. Will Ferrell, Glen Hansard

Aired: 3/17/2015

102. Norm MacDonald, Theo James

Aired: 3/18/2015

103. Ben Stiller, Tove Lo

Aired: 3/23/2015

104. Bill O'Reilly, Aubrey Plaza

Aired: 3/24/2015

105. James Franco, Jake Johannsen, Action Bronson

Aired: 3/25/2015

106. Neil Patrick Harris, Charlie Cox, the Suffers

Aired: 3/30/2015

107. David Duchovny, Josh Gad, Houndmouth

Aired: 3/31/2015

108. Sen. Al Franken, Billy Eichner, David Sanborn

Aired: 4/1/2015

109. Kelly Ripa, Aasif Mandvi, Fat White Family

Aired: 4/2/2015

110. Mike Myers, Nick Griffin, Banks

Aired: 4/3/2015

111. Sarah Jessica Parker, Julie Chen, Asleep at the Wheel

Aired: 4/13/2015

112. Billy Crystal, Chris Russo, Chris Stapleton

Aired: 4/14/2015

113. Michael J. Fox, Iron & Wine, Ben Bridwell

Aired: 4/15/2015

114. Kevin James, Tom Dreesen, Tracy Chapman

Aired: 4/16/2015

115. Alec Baldwin, John Mayer

Aired: 4/17/2015

116. John Travolta, Amy Schumer, the Waterboys

Aired: 4/20/2015

117. Piedmont Bird Callers, Paul Rudd

Aired: 4/21/2015

118. Bruce Willis, Dawes

Aired: 4/22/2015

119. Robert Downey Jr., Chris Russo, Elvis Costello

Aired: 4/23/2015

120. Jerry Seinfeld, Jason Isbell & Amanda Shires

Aired: 4/24/2015

121. Scarlett Johansson, John Mellencamp, Todd Rundgren

Aired: 4/27/2015

122. Michael Keaton, Future Islands

Aired: 4/28/2015

123. Jack Hanna, John Popper

Aired: 4/29/2015

124. First Lady Michelle Obama Hootie and the Blowfish

Aired: 4/30/2015

125. Steve Martin, Emmylou Harris, Rodney Crowell, Amos Lee, Ralph Stanley, Mark O'Connor

Aired: 5/1/2015

126. President Barack Obama, Will Ferrell, the Avett Brothers, Brandi Carlile

Aired: 5/4/2015

127. Reese Witherspoon, Nathan Lane, Mumford & Sons

Aired: 5/5/2015

128. Martin Short, Norah Jones

Aired: 5/6/2015

129. Tina Fey, First Aid Kit

Aired: 5/7/2015

130. Ray Romano, Brian Regan, Dave Matthews Band

Aired: 5/8/2015

131. Howard Stern, Don Rickles

Aired: 5/11/2015

132. Bill Clinton, Adam Sandler

Aired: 5/12/2015

133. Julia Roberts, Paul Shaffer, Ryan Adams

Aired: 5/13/2015

134. Al Pacino, George Clooney, Tom Waits

Aired: 5/14/2015

135. Oprah Winfrey, Norm Macdonald

Aired: 5/15/2015

136. Tom Hanks, Eddie Vedder

Aired: 5/18/2015

137. Bill Murray, Bob Dylan

Aired: 5/19/2015

138. The Final Late Show with David Letterman

Aired: 5/20/2015

6,028th broadcast

149. Episode 149

Aired: 5/20/2015

The final episode includes surprises, memorable highlights and the last Top Ten List.